期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 145, 期 -, 页码 1-10出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.12.067
关键词
Ultrasound; Pyrimidine; Azole; Antimicrobial activity
资金
- University Grants Commission (UGC), New Delhi [F.17-142/98(SA-I)]
- University Grants Commission (UGC), New Delhi
A new class of methylthio linked pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles were prepared under conventional and ultrasound irradiation methods. All the compounds were obtained in higher yields and in shorter reaction times in ultrasound irradiation method when compared with the conventional method. The title compounds were tested for antimicrobial activity. The compounds 12c and 12f exhibited promising antibacterial activity against P. aeruginosa whereas the compounds 13c and 13f showed pronounced antifungal activity against A. niger. (C) 2017 Elsevier Masson SAS. All rights reserved.
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