期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 143, 期 -, 页码 150-156出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.11.033
关键词
4-aminoquinoline-phthalimides; Microwave synthesis; Anti-plasmodial evaluation; Cytotoxicity; Selectivity index
资金
- Council of Scientific and Industrial research (CSIR), New Delhi, India, under CSIR-JRF Fellowship [09/254(0269)/2017-EMR-1]
- Science and Engineering Research Board (SERB), New Delhi [EMR/2015/001687]
Microwave promoted high yielding synthesis of 4-aminoquinoline-phthalimides was developed with an aim to evaluate their anti-plasmodial potential. The scaffolds with longer spacer length (n = 6, 8) between two pharmacophores and a halogen substituent on the phthalimide ring displayed good anti-plasmodial activity. Compound 5w, with an optimum combination of hexyl chain as spacer along with a tetra-bromophthalimide ring proved to be most potent and non-cytotoxic among the series exhibiting an IC50 value of 0.10 mu M. (C) 2017 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据