期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 144, 期 -, 页码 435-443出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.12.056
关键词
Indolizine; Chalcone; Hybrid; Aldol condensation; Anticancer activity
资金
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2017R1A2A2A05069364]
- Korea Research Institute of Chemical Technology [KK1703-F02]
A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero) aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells. (C) 2017 Elsevier Masson SAS. All rights reserved.
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