期刊
EUROPEAN JOURNAL OF CANCER
卷 91, 期 -, 页码 11-20出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2017.12.005
关键词
PD-L1; Immune checkpoint inhibitor; Immune stromal PD-L1; Rectal cancer; CD8; T cell; Chemoradiotherapy; Immunotherapy; Tumour-infiltrating lymphocyte; Synergistic effect
类别
资金
- JSPS KAKENHI [15K10156]
- Grants-in-Aid for Scientific Research [15K06861, 15K10156] Funding Source: KAKEN
Background: The synergistic effect of combining immune checkpoint inhibitors with radiotherapy was reported recently, but there are few studies on programmed cell death-ligand 1 (PD-L1) expression in rectal cancer treated by preoperative chemoradiotherapy (CRT). The aim of the present study was to investigate the PD-L1 expression status before and after CRT and its association with clinicopathological characteristics and recurrence in rectal cancer. Methods: Immunostainings of PD-L1 and CD8 were performed in 287 patients with rectal cancer treated by CRT. PD-L1 expression on the tumour cells (tPD-L1) and on the stromal immune cells (iPD-L1) was evaluated before and after CRT. CD8+ cell density in tumour area (tCD8+) before CRT and in the stromal area (sCD8+) before and after CRT was also evaluated. Results: High tPD-L1 expression was observed in only three patients (1.0%). High iPD-L1 expression significantly increased from 31.7% before CRT to 49.2% after CRT (P < 0.0001). The increase in high iPD-L1 expression after CRT was only observed in patients with tumour regression grades 1 and 2. High iPD-L1 expression was associated with high tCD8+ cell density before CRT (P < 0.0001) and sCD8+ cell density after CRT (P < 0.0001). High tCD8+ cell density before CRT was associated with better disease-free survival (DFS) (P = 0.0331), but its improved effect on DFS could be observed in patients with high iPD-L1 expression (P = 0.0081), not in patients with low iPD-L1 expression (P = 0.516). Conclusion: The present study demonstrated the significant correlations between iPD-L1 expression and CD8+ cell density both before and after CRT. (C) 2017 Elsevier Ltd. All rights reserved.
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