期刊
EXTRACELLULAR VESICLES AND MECHANISMS OF CELL-CELL COMMUNICATION
卷 62, 期 2, 页码 149-163出版社
PORTLAND PRESS LTD
DOI: 10.1042/EBC20170080
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资金
- NATIONAL CANCER INSTITUTE [R01CA206458, R01CA163592] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM117916] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA206458, R01 CA163592] Funding Source: Medline
- NIGMS NIH HHS [R01 GM117916] Funding Source: Medline
Extracellular vesicles (EVs) are membrane vesicles that are released from cells and mediate cell-cell communication. EVs carry protein, lipid, and nucleic acid cargoes that interact with recipient cells to alter their phenotypes. Evidence is accumulating that tumor-derived EVs can play important roles in all steps of cancer progression. Here, we review recent studies reporting critical roles for EVs in four major areas of cancer progression: promotion of cancer invasiveness and motility, enhancement of angiogenesis and vessel permeability, conditioning premetastatic niches, and immune suppression.
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