期刊
REPRODUCTION
卷 150, 期 1, 页码 R25-R34出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/REP-14-0643
关键词
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资金
- National Natural Science Foundation of China [31230048, 31171422, 31401250]
- Chinese Ministry of Science and Technology [2014CB943101, 2013CB947901]
- Shanghai Institutions of Higher Learning [2012.53]
- Science and Technology Commission of Shanghai Municipality [12JC1405900]
- Key Discipline and Specialty Foundation of Shanghai Municipal Commission of Health and Family Planning
- Shanghai Pujiang Program [11PJ1406400]
Spermatogenesis is composed of three distinctive phases, which include self-renewal of spermatogonia via mitosis, spermatocytes undergoing meiosis I/II and post-meiotic development of haploid spermatids via spermiogenesis. Spermatogenesis also involves condensation of chromatin in the spermatid head before transformation of spermatids to spermatozoa. Epigenetic regulation refers to changes of heritably cellular and physiological traits not caused by modifications in the DNA sequences of the chromatin such as mutations. Major advances have been made in the epigenetic regulation of spermatogenesis. In this review, we address the roles and mechanisms of epigenetic regulators, with a focus on the role of microRNAs and DNA methylation during mitosis, meiosis and spermiogenesis. We also highlight issues that deserve attention for further investigation on the epigenetic regulation of spermatogenesis. More importantly, a thorough understanding of the epigenetic regulation in spermatogenesis will provide insightful information into the etiology of some unexplained infertility, offering new approaches for the treatment of male infertility.
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