期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 37, 期 7, 页码 1799-1810出版社
WILEY
DOI: 10.1002/etc.4144
关键词
Toxic effects; Nanoparticles; Bioaccumulation; Characterization; Reproducibility
资金
- Research Council of Norway through the NANoREG project [310584]
- NANOCHARM project [221391]
Using Caenorhabditis elegans as a model organism, we addressed the potential linkage among toxicity of NM300K Ag nanoparticles (AgNPs), their particle size distribution, and the presence of dissolved Ag in the test media. Of the 3 endpoints assessed (growth, fertility, and reproduction), reproduction was the most sensitive, with the 50% effect concentration (EC50) ranging from 0.26 to 0.84mgAgL(-1) and 0.08 to 0.11mgAgL(-1) for NM300K and AgNO3, respectively. Silver uptake by C. elegans was similar for both forms of Ag, whereas bioaccumulation was higher in AgNO3 exposure. The observed differences in toxicity between NM300K and AgNO3 did not correlate with bioaccumulated Ag, which suggests that toxicity is a function of the type of exposing agent (AgNPs vs AgNO3) and its mode of action. Before addition of the food source (Escherichia coli), size fractionation revealed that dissolved Ag comprised 13 to 90% and 4 to 8% of total Ag in the AgNO3 and NM300K treatments, respectively. No dissolved Ag was detectable in the actual test media due to immediate Ag adsorption to bacteria. The results of the present study indicate that information on behavior and characterization of exposure conditions is essential for nanotoxicity studies. Environ Toxicol Chem 2018;37:1799-1810. (c) 2018 SETAC
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