期刊
ENVIRONMENTAL RESEARCH
卷 166, 期 -, 页码 215-222出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2018.06.002
关键词
Selenium; Pregnancy; Children; Neurodevelopment; Nutrient
资金
- European Union [282957, HEALTH.2010.2.4.5-1]
- Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041, FIS-FEDER: PI03/1615, PI04/1509, P04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI14/0891, PI14/1687, PI16/1288, CP11/0178, CP15/0025, CPII16/0051]
- Fundacio per al Foment de la Investigacio Sanitaria i Biomedica de la Comunitat Valenciana -FISABIO [UGP-15-230, UGP-15-244, UGP-15-249]
- Conselleria de Sanitat
- Generalitat Valenciana
- Karolinska Institutet
Background: The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex and cord blood mercury was also evaluated. Methods: Study subjects were 490 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2012). Child neuropsychological development was assessed at around 5 years of age by the McCarthy Scales of Children's Abilities (MSCA). Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation and at 5 years of age. Se was measured in serum samples by ICP-MS at the end of the first trimester of pregnancy (mean +/- standard deviation (SD) = 12.4 +/- 0.6 weeks of gestation). Results: The mean +/- SD of maternal serum Se concentrations was 79.9 +/- 8.1 mu g/L. In multivariate analysis, no linear association was found between Se concentrations and the nine MSCA scales. Generalized additive models indicated inverted U-shaped relationships between Se concentrations and the verbal and global memory scales. When assessing the influence of effect modifiers, breastfeeding played a role: the association between Se and neuropsychological development was inverted U-shaped for the quantitative, general cognitive, working memory, fine motor, global motor and executive function scales only for non-breastfed children. Conclusion: Low and high maternal Se concentrations seem to be harmful for child neuropsychological development, however further studies should explore this non-linear relationship.
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