期刊
ENVIRONMENTAL POLLUTION
卷 234, 期 -, 页码 71-78出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2017.11.050
关键词
Sulfadiazine; Ciprofloxacin; Opportunistic pathogens; Antibiotic resistance genes; Extracellular polymeric substances
资金
- National Natural Science Foundation of China [51290281]
- project of Chinese Academy of Sciences [QYZDY-SSW-DQC004]
- Federal Department of Chinese Water Control and Treatment [2017ZX07108, 2017ZX07501002]
Effects of sulfadiazine and ciprofloxacin on the occurrence of free-living and particle-associated opportunistic pathogens in bulk water of simulated drinking water distribution systems (DWDSs) were investigated. It was found that sulfadiazine and ciprofloxacin greatly promoted the occurrence of opportunistic pathogens including Pseudomonas aeruginosa, Legionella pneumophila, Mycobacterium avium and its broader genus Mycobacterium spp., as well as the amoebae Acanthamoeba spp. and Hartmanella vermiformis, in bulk water of DWDSs. Moreover, sulfadiazine and ciprofloxacin exhibited much stronger combined effects on the increase of these opportunistic pathogens. Based on the analysis of the antibiotic resistance genes (ARGs) and extracellular polymeric substances (EPS), it was verified that EPS production was increased by the antibiotic resistant bacteria arising from the effects of sulfadiazine/ciprofloxacin. The combined effects of sulfadiazine and ciprofloxacin induced the greatest increase of EPS production in DWDSs. Furthermore, the increased EPS with higher contents of proteins and secondary structure beta-sheet led to greater bacterial aggregation and adsorption. Meanwhile, large numbers of suspended particles were formed, increasing the chlorine-resistance capability, which was responsible for the enhancement of the particle-associated opportunistic pathogens in bulk water of DWDSs with sulfadiazine/ciprofloxacin. Therefore, sulfadiazine and ciprofloxacin promoted the occurrence of particle associated opportunistic pathogens in bulk water of DWDSs due to the role of EPS produced by the bacteria with ARGs. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据