期刊
ENVIRONMENTAL POLLUTION
卷 232, 期 -, 页码 556-562出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2017.09.087
关键词
Pregnancy; Polycyclic aromatic hydrocarbons; Exposure assessment
资金
- National Institutes of Health (NIH) [UG3OD023251]
- National Institute of Environmental Health Sciences (NIEHS) [R01ES018872, P42ES017198, P50ES026049, U2CES026553]
- US Environmental Protection Agency (EPA) [R836155]
- Intramural Research Program of the NIEHS
- EPA [R836155, 909389] Funding Source: Federal RePORTER
Pregnant women and their fetuses represent susceptible populations to environmental contaminants. Exposure to polycyclic aromatic hydrocarbons (PAHs) among pregnant women may contribute to adverse birth outcomes such as preterm birth. Multiple previous studies have assessed airborne sources of PAHs among pregnant women but few have measured urinary PAH metabolites which can capture total. exposure through multiple routes. The aim of this study was to bridge this knowledge gap by assessing longitudinal urinary PAH metabolite concentrations over two time points in pregnancy cohorts in Boston (N = 200) and Puerto Rico (N = 50) to better understand exposure distributions throughout pregnancy and how they relate to demographic factors. Urine samples were analyzed for 1-NAP, 2-NAP, 2-FLU, 1-PHE, 2,3-PHE, 4-PHE, 9-PHE, and 1-PYR. Concentrations of 2-NAP, 1-PYR, and 4-PHE were higher in Puerto Rico, while all other metabolites were present in higher concentrations in Boston. In Puerto Rico, intraclass correlation coefficients (ICC) were weak to moderate, ranging from 0.06 to 0.42. PAH metabolite concentrations were significantly higher among younger, heavier (except 1-NAP and 9-PHE), and less educated individuals in Boston only. Consistent significant associations between PAH concentrations and measured covariates were not found in Puerto Rico. Our results suggest that potentially important differences in PAH exposure exist between these two populations. Additionally, our results indicate that multiple urinary measurements are required to accurately assess PAH exposure throughout pregnancy. (C) 2017 Elsevier Ltd. All rights reserved.
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