期刊
ENVIRONMENTAL POLLUTION
卷 234, 期 -, 页码 953-959出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2017.12.034
关键词
Graphene oxide; Daphnia magna; Acute toxicity; Oxidative stress; Bioaccumulation
资金
- National Natural Science Foundation of China [41373089, 41573094]
- Fundamental Research Project of Shenzhen, China [JCYJ20150331151536446, JCYJ20150529164918736, JCYJ20160531195354516]
- Shenzhen Peacock Plan Research Grant [KQCX201533115153644]
Graphene oxide (GO) possesses versatile applicability and high hydrophilicity, thus may have frequent contact with aquatic organisms. However, the ecological risks of GO in aquatic ecosystems remain largely unexplored currently. This study evaluated the comprehensive toxicological effects of GO on Daphnia magna, a key species in fresh water ecosystem. The results revealed nonsevere acute toxicities, including immobility (72 h EC50: 443 mg/L) and mortality (72 h LC50: 45.4 mg/L), of GO on D. magna. To understand the underlying mechanism of GO exposure, changes in superoxide dismutase (SOD) and lipid peroxidation (LPO) of D. magna exposed to GO were correlated, which revealed elevated GO-mediated oxidative stress and damages, especially in the long-time and high-dose exposure groups. The observations of in vivo fluorescence labeled with 2', 7'-dichlorofluorescin further demonstrated that reactive oxygen species were concentrated in daphnia guts, which corresponded with the high bioaccumulation level (5 mg/L, 24 h body burden: 107.9 g/kg) of GO in daphnia guts. However, deputation of GO from daphnia was not difficult. Daphnia almost released all GO within 24 h after it was transferred to clean water. These results hence suggest that GO could accumulate and induce significant oxidative stress in the gut of D. magna, while D. daphnia can also relieve the acute toxicity by depurating GO. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据