期刊
CHINESE JOURNAL OF NATURAL MEDICINES
卷 13, 期 8, 页码 578-587出版社
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(15)30053-4
关键词
Diosgenin; Steroid sapogenin; Pharmacological activities; Multiple targets
资金
- National Natural Science Foundation of China [81274131]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- 2011 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range of pharmacological activities in preclinical studies. It exhibits anticancer, cardiovascular protective, anti-diabetes, neuroprotective, immunomodulatory, estrogenic, and skin protective effects, mainly by inducing apoptosis, suppressing malignant transformation, decreasing oxidative stress, preventing inflammatory events, promoting cellular differentiation/proliferation, and regulating T-cell immune response, etc. It interferes with cell death pathways and their regulators to induce apoptosis. Diosgenin antagonizes tumor metastasis by modulating epithelial-mesenchymal transition and actin cytoskeleton to change cellular motility, suppressing degradation of matrix barrier, and inhibiting angiogenesis. Additionally, diosgenin improves antioxidant status and inhibits lipid peroxidation. Its anti-inflammatory activity is through inhibiting production of pro-inflammatory cytokines, enzymes and adhesion molecules. Furthermore, diosgenin drives cellular growth/differentiation through the estrogen receptor (ER) cascade and transcriptional factor PPAR.. In summary, these mechanistic studies provide a basis for further development of this compound for pharmacotherapy of various diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据