期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2015.00045
关键词
intrinsically disordered proteins; IDP ensembles; IDP function; disorder prediction; protein ensemble database
资金
- Odysseus (FWO, Research Foundation Flanders) [G.0029.12]
- VIB international postdoctoral (omics@VIB) Marie-Curie COFUND fellowship
- Brussels Institute for Research and Innovation (Innoviris) [BB2B 2010-1-12]
Intrinsically disordered proteins (IDPs) are ubiquitously involved in cellular processes and often implicated in human pathological conditions. The critical biological roles of these proteins, despite not adopting a well-defined fold, encouraged structural biologists to revisit their views on the protein structure-function paradigm. Unfortunately, investigating the characteristics and describing the structural behavior of IDPs is far from trivial, and inferring the function(s) of a disordered protein region remains a major challenge. Computational methods have proven particularly relevant for studying IDPs: on the sequence level their dependence on distinct characteristics determined by the local amino acid context makes sequence-based prediction algorithms viable and reliable tools for large scale analyses, while on the structure level the in silico integration of fundamentally different experimental data types is essential to describe the behavior of a flexible protein chain. Here, we offer an overview of the latest developments and computational techniques that aim to uncover how protein function is connected to intrinsic disorder.
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