期刊
ENVIRONMENT INTERNATIONAL
卷 117, 期 -, 页码 146-153出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2018.05.011
关键词
Antibiotic resistance genes; Human pathogens; Horizontal gene transfer; Human health; Urban environment
资金
- Natural Science Foundation of China [31722004]
- National Key Research and Development Program of China-International collaborative project from Ministry of Science and Technology [2017YFE0107300]
- Knowledge Innovation Program of the Chinese Academy of Sciences [IUEQN201504]
- K.C Wong Education Foundation
- Youth Innovation Promotion Association, CAS
Wastewater treatment plants (WWTPs) contain diverse antibiotic resistance genes (ARGs), and thus are considered as a major pathway for the dissemination of these genes into the environments. However, comprehensive evaluations of ARGs dynamic during wastewater treatment process lack extensive investigations on a broad spectrum of ARGs. Here, we investigated the dynamics of ARGs and bacterial community structures in 114 samples from eleven Chinese WWTPs using high-throughput quantitative PCR and 16S rRNA-based Illumina sequencing analysis. Significant shift of ARGs profiles was observed and wastewater treatment process could significantly reduce the abundance and diversity of ARGs, with the removal of ARGs concentration by 1-2 orders of magnitude. Whereas, a considerable number of ARGs were detected and enriched in effluents compared with influents. In particular, seven ARGs mainly conferring resistance to beta-lactams and aminoglycosides and three mobile genetic elements persisted in all WWTPs samples after wastewater treatment. ARGs profiles varied with wastewater treatment processes, seasons and regions. This study tracked the footprint of ARGs during wastewater treatment process, which would support the assessment on the spread of ARGs from WWTPs and provide data for identifying management options to improve ARG mitigation in WWTPs.
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