期刊
ENVIRONMENT INTERNATIONAL
卷 117, 期 -, 页码 276-283出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2018.05.018
关键词
Fine particulate matter (PM2.5); Reactive oxygen species (ROS); Biotic assay; Health effect
资金
- BK21 PLUS [22A20130012682]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2014R1A2A2A04007801]
Substantial increase in level of particulate matter has raised concerns in South Korea recently. Ambient particulate matter is classified as Group I carcinogen (IARC, 2013) and multiple epidemiological studies has demonstrated adverse health effects due to exposure of particulate matter. Fine particulate matter (PM2.5) which has a diameter < 2.5 mu m is likely to penetrate deeply into lung and is known to be eliciting adverse health effects. A number of epidemiological studies have been conducted on adverse health effects of PM-related diseases and mortality rate, yet particulate matter (PM)-induced reactive oxygen species (ROS) activity at the cellular level has not been actively studied in Korea. This study assessed PM-induced oxidative potential by exposure of collected ambient PM2.5 samples to the rat alveolar macrophage cell line. The characteristics of PM2.5 in Korea were further characterized by linking chemical constituents and contributing sources to ROS. PM2.5 mass concentration during the cold season was relatively higher than mass concentration during the warm season and chemical constituents except for Secondary Organic Carbon (SOC) and SO42- which both showed similar trends in both the cold and cold seasons. The concentration of crustal elements was especially high during the cold season which can be an indication of long range transport of Asian dust. Water soluble organic carbon and water soluble transition metals (Cr and Zn) were also shown to be correlated to oxidative potential and metals such as As and V were shown to have a high contribution to ROS activity according to stepwise multiple linear regression. Principal Component Analysis (PCA) results identified six factors that can be interpreted as soil, mobile, industry, secondary inorganic aerosol, secondary organic aerosol and oil combustion. Moreover, through Principal Component Regression (PCR), industry, soil, mobile and SIA were shown to be statistically significant sources in a relation to ROS activity.
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