期刊
JOURNAL OF CHEMICAL SCIENCES
卷 127, 期 5, 页码 959-966出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-015-0853-7
关键词
Wedelolactone; boron-doped diamond electrode; impedance; voltammetry
资金
- Ministry of Human Resource Development project, Dayalbagh Educational Institute, Dayalbagh, Agra, India
- UGC
Boron-doped diamond electrode has been utilized for the study of electrochemical behaviour of an anti-HIV herbal drug wedelolactone in Britton-Robinson buffer (pH-2.5) by square-wave and cyclic voltammetry techniques. The response characteristics of cyclic voltammetry and square wave voltammetry showed a remarkable increase in the anodic peak current and electrochemical impedance spectroscopy revealed a lowering in charge transfer resistance at the boron-doped diamond electrode as compared to the glassy carbon electrode that can be attributed to the higher sensitivity of boron-doped diamond sensor. Cyclic voltammetry at the boron-doped diamond surface revealed the oxidation of wedelolactone with two oxidation peaks (P-1 and P-2) with Ep(1)= 0.4V and Ep(2)=1.00 V with scan rate varying from 10 - 220 mV/s and exhibits diffusion-controlled process. Based on the electrochemical measurements, a probable oxidation mechanism has been deduced and the electrode dynamics parameters have been evaluated. The effect of concentration on the peak currents of wedelolactone was found to have a linear relationship within the concentration range of 50-700 ng/mL. The LOD and LOQ were found to be 43.87 and 132.93 ng/mL respectively. The applicability of the proposed method was further scrutinized by the successful determination of wedelolactone in real plant samples.
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