期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 47, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emm.2014.99
关键词
-
资金
- National Research Foundation (NRF)
- Ministry of Science, ICT & Future Planning, Korean government through National Nuclear Technology Program [NRF-2013M2A2A7066345, NRF-2012M2B2B1055639]
- National Research Foundation of Korea [2012M2B2B1055639] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of mesenchymal phenotypes of basal-type breast cancer cells remain obscure. Here, we report that KRAS is a critical regulator for the maintenance of mesenchymal features in basal-type breast cancer cells. KRAS is preferentially activated in basal-type breast cancer cells as compared with luminal type. By loss and gain of KRAS, we found that KRAS is necessary and sufficient for the maintenance of mesenchymal phenotypes and metastatic ability through SLUG expression. Taken together, this study demonstrates that KRAS is a critical regulator for the metastatic behavior associated with mesenchymal features of breast cancer cells, implicating a novel therapeutic target for basal-type breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据