期刊
FRONTIERS IN HUMAN NEUROSCIENCE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2015.00561
关键词
basal ganglia network; resting-state fMRI; independent component analysis; functional connectivity; schizophrenia
资金
- National Nature Science Foundation of China [81471638, 91232725, 81330032, 81571759]
- Special-Funded Program on National Key Scientific Instruments and Equipment Development of China [2013YQ490859]
- Program for Changjiang Scholars and Innovative Research Team [IRT0910]
- 111 project [B12027]
The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.
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