期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 20, 期 -, 页码 440-457出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4318
关键词
Poly-ADP-ribose; PARP; chromatin; DNA damage response; Review
资金
- DFG [TI 817/2-1]
- DAAD [55934632]
Poly-ADP-ribosylation is a post-translational modification generated in high amounts by poly-ADP-ribose polymerases (PARPs) in response to cellular stress, especially genotoxic stimuli. DNA damage-induced PARylation significantly changes local chromatin structure and triggers the accumulation of several DNA damage response (DDR) proteins at the DNA lesions. In this review, we will discuss the regulation of chromatin structure and DNA damage repair machineries by DNA damage-induced poly-ADP-ribosylation.
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