期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 20, 期 -, 页码 838-871出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4341
关键词
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资金
- China Agriculture Research System [CARS-36]
- National Basic Research Program of China [2010CB35701, 2012CB723700]
- National Science and Technology Support Program [2012BAD39B01-5]
- Science and Technology Program of Guangdong Province [2009B090200067]
- National Natural Science Foundation of China [31272450]
- Agriculture and Food Research Initiative Competitive Grant from the USDA National Institute of Food and Agriculture [2008-35203-19120, 2011-67015-20028, 2014-67015-21770]
- Texas A&M AgriLife Research [H-8200]
- NIFA [2011-67015-20028, 579894] Funding Source: Federal RePORTER
Water and ion accumulation is the driving force for rapid expansion of the amnion and allantois of mammalian placentae during early gestation, and, therefore, essential for embryonic/fetal growth and survival. Aquaporins (AQP) are a family of small integral plasma membrane proteins that primarily transport water across the plasma membrane. To date, thirteen AQP isoforms (AQP 0-12) have been identified in mammals. AQP 1, 2, 3, 4, 5, 6, 7, 8, 9, and 11 are expressed in the female reproductive tract. Based on their structural and functional properties, AQPs are divided into three subgroups: classical aquaporins (AQP 0, 1, 2, 4, 5, 6, and 8), aquaglyceroporins (AQP 3, 7, 9, and 10), and superaquaporins (AQP 11 and 12). Expression of AQPs in the uterus and placenta is regulated by hormones and nutrients to maintain fluid homeostasis in the conceptus. The underlying mechanisms may involve signal transduction pathways mediated by cAMP, MAPK, PKC, and PI3K/Akt/mTOR. Such new knowledge will advance basic understanding of mammalian reproductive biology to enhance embryonic/fetal survival, growth and development in women and livestock.
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