期刊
EMBO MOLECULAR MEDICINE
卷 10, 期 4, 页码 -出版社
WILEY
DOI: 10.15252/emmm.201708300
关键词
Alzheimer's disease; blood-CSF barrier; choroid plexus; therapy; TNF receptor 1
资金
- Research Foundation-Flanders (FWO)
- Concerted Research Actions of Ghent University
- Foundation for Alzheimer's Research Belgium (SAO-FRA)
- EU Cost action MouseAge [BM1402]
- Baillet Latour Fund
- CLEM grant
Alzheimer's disease (AD) is the most common form of dementia, and neuroinflammation is an important hallmark of the pathogenesis. Tumor necrosis factor (TNF) might be detrimental in AD, though the results coming from clinical trials on anti-TNF inhibitors are inconclusive. TNFR1, one of the TNF signaling receptors, contributes to the pathogenesis of AD by mediating neuronal cell death. The blood-cerebrospinal fluid (CSF) barrier consists of a monolayer of choroid plexus epithelial (CPE) cells, and AD is associated with changes in CPE cell morphology. Here, we report that TNF is the main inflammatory upstream mediator in choroid plexus tissue in AD patients. This was confirmed in two murine AD models: transgenic APP/PS1 mice and intracerebroventricular (icv) AO injection. TNFR1 contributes to the morphological damage of CPE cells in AD, and TNFR1 abrogation reduces brain inflammation and prevents blood-CSF barrier impairment. In APP/PS1 transgenic mice, TNFR1 deficiency ameliorated amyloidosis. Ultimately, genetic and pharmacological blockage of TNFR1 rescued from the induced cognitive impairments. Our data indicate that TNFR1 is a promising therapeutic target for AD treatment.
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