期刊
MOLECULAR AND CLINICAL ONCOLOGY
卷 3, 期 5, 页码 1129-1134出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mco.2015.604
关键词
magnetic resonance imaging; apparent diffusion coefficient; diffusion-weighted magnetic resonance imaging; chemoradiotherapy; radiotherapy; S-1; rectal cancer; irinotecan; preoperative radiotherapy; neoadjuvant chemoradiotherapy
类别
The purpose of this study was to investigate the clinical value of diffusion-weighted (DW) magnetic resonance imaging (MRI) as a predictor of tumor response in patients receiving neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer (RC) through measurement of the apparent diffusion coefficient (ADC) value in each tumor. Neoadjuvant radiotherapy with a total dose of 45 Gy in 25 fractions was performed in all 16 patients with RC, combined with irinotecan and S-1. MRI was performed before and after NA-CRT. Multiple factors were assessed to predict the pathological response to NA-CRT. The pathological response rate was determined in 9 patients (56.3%). Statistical analyses indicated that the ADC value prior to NA-CRT was significantly lower in patients with a better response to NA-CRT (P=0.023). A cut-off value of 0.750x10(-3) mm(2)/sec obtained by a receiver operating characteristic curve analysis indicated a sensitivity of 77.8% and specificity of 85.7% for pathological responders to NA-CRT. In addition, the patients with lower ADC values exhibited a greater pathological response to NA-CRT (P=0.041). In conclusion, the ADC value of MRI of RC patients treated with NA-CRT followed by surgery may provide valuable information to predict the response to NA-CRT.
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