期刊
KIDNEY RESEARCH AND CLINICAL PRACTICE
卷 34, 期 3, 页码 165-169出版社
ELSEVIER INC
DOI: 10.1016/j.krcp.2015.08.001
关键词
Kidney; Micro fluidics; Organ-on-a-chip
资金
- National Research Foundation of Korea [2013R1A1A1012689]
- Korean Association of Internal Medicine Research Grant
- National Research Foundation of Korea [2013R1A1A1012689] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ -on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys -on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip. Copyright (C) 2015. The Korean Society of Nephrology. Published by Elsevier.
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