期刊
REGENERATIVE BIOMATERIALS
卷 2, 期 3, 页码 221-228出版社
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbv015
关键词
biomaterial; biomimetic; biphasic scaffold; osteochondral regeneration; tissue engineering
资金
- National Natural Science Foundation of China [51303174, 51273196, 51203153, 51233004, 51390484, 51321062]
- Scientific Development Program of Jilin Province [20140520050JH, 20140309005GX]
- Science and Technology Planning Project of Changchun City [14KG045]
The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structures of osteochondral tissues have been developed to close this chasm. A variety of biomimetic bilayer scaffolds fabricated from natural or synthetic polymers, or the ones loading with growth factors, cells, or both of them make great progresses in osteochondral defect repair. In this review, the preparation and in vitro and/or in vivo verification of bioinspired biphasic scaffolds are summarized and discussed, as well as the prospect is predicted.
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