期刊
NATURE REVIEWS IMMUNOLOGY
卷 15, 期 9, 页码 559-573出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3877
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资金
- Wellcome Trust Research Career Development Fellowship [WT097411MA]
- Lister Institute of Preventive Medicine
- Wellcome Trust [WT108246AIA]
- Imperial College and the Royal Society [RG130811]
- MRC [MR/J006874/1] Funding Source: UKRI
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton-actin, microtubules, intermediate filaments and septins, which are well known for their roles in cell division, shape and movement have important functions in innate immunity and cellular self-defence. Investigations using cellular and animal models have shown that these cytoskeletal proteins are crucial for sensing bacteria and for mobilizing effector mechanisms to eliminate them. In this Review, we highlight the emerging roles of the cytoskeleton as a structural determinant of cell-autonomous host defence.
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