期刊
ANIMAL NUTRITION
卷 1, 期 3, 页码 85-95出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.aninu.2015.07.005
关键词
Amino acids; Secreted phosphoprotein 1; Pregnancy; Interferon tau; Conceptus development; Trophectoderm
资金
- National Research Initiative Competitive Grant from Animal Reproduction Program of the USDA National Institute of Food and Agriculture [2008-35203-19120, 2009-35206-05211, 2011-67015-20067, 2011-67015-20028]
- National Research Initiative Competitive Grant from Animal Growth & Nutrient Utilization Program of the USDA National Institute of Food and Agriculture [2008-35206-18764]
- Texas A&M AgriLife Research [H-8200]
The dialogue between the mammalian conceptus (embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical pen-implantation period of pregnancy when the stage is set for implantation and placentation that precedes fetal development. Uterine epithelial cells secrete and/or transport a wide range of molecules, including nutrients, collectively referred to as histotroph that are transported into the fetal-placental vascular system to support growth and development of the conceptus. The availability of uterine-derived histotroph has long-term consequences for the health and well-being of the fetus and the prevention of adult onset of metabolic diseases. Histotroph includes numerous amino acids, but arginine plays a particularly important role as a source of nitric oxide and polyamines required for fetal-placental development in rodents, swine and humans through mechanisms that remain to be fully elucidated. Mechanisms whereby arginine regulates expression of genes via the mechanistic target of rapamycin cell signaling pathways critical to conceptus development, implantation and placentation are discussed in detail in this review. (C) 2015 Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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