4.6 Article

Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition

期刊

PHARMACEUTICALS
卷 8, 期 3, 页码 637-663

出版社

MDPI
DOI: 10.3390/ph8030637

关键词

herbal medicine; conventional medicine; CYP450; malaria; HIV/AIDS; hypertension; bleeding disorders; pharmacogenetics

资金

  1. South African Medical Research Council (SAMRC) under a Self-Initiated Research Grant
  2. National Research Foundation (NRF) under an Indigenous Knowledge Systems Research Grant
  3. NRF

向作者/读者索取更多资源

The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level.

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