期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 161, 期 -, 页码 655-661出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2018.06.046
关键词
HgCl2; Luteolin; PI3K/AKT/Nrf2; Cardiac damage; Apoptosis; Flavonoid compound
资金
- National Natrual Science Foundation of China [31101868]
- Scientific Research Foundation for Excellent Returned Scholars of Heilongjiang Province
- University Nursing Program for Young Scholar with Creative Talents in Heilongjiang Province [UNPYSCT-2016012]
- Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province [LBH-Q16013]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of Heilongjiang Province [LC2017007]
- Academic Backbone Support Program [15XG17]
Inorganic mercury is a toxic metal of worldwide concern, and causes serious cardiac injury. However, effective treatment for cardiac injury induced by mercuric chloride (HgCl2) has not been fully identified. Luteolin (Lut) is a novel natural antioxidant. This study aimed to investigate the role of Lut on HgCl2-induced cardiac injury. Male Wistar rats were randomly assigned to 4 groups, control, Lut (80 mg/kg intragastrically), HgCl2 (80 mg/L, in drinking water), and HgCl2 + Lut groups. The results indicated that Lut significantly ameliorated cardiac histopathological damage, oxidative stress, and apoptosis induced by HgCl2 in the rat heart. Furthermore, Lut evidently increased levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor-erythroid-2-related factor 2 (Nrf2) and its downstream proteins, and inhibited NF-kappa B activation in the heart of rats treated by HgCl2. Taken together, our findings suggest that activating PI3K/AKT/Nrf2 signaling pathway is involved in the protective effect of Lut against HgCl2-induced cardiac damage.
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