期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 182, 期 8, 页码 694-704出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwv105
关键词
aging; antioxidants; dietary supplements; minerals; randomized controlled trial; vitamins
资金
- Fruit d'Or Recherche (Rueil-Malmaison)
- Lipton (Rueil-Malmaison)
- Cereal (Annonay)
- Candia (Lyon)
- Kellogg's (Rosny-sous-Bois)
- CERIN (Paris)
- LU/Danone (Paris)
- Sodexho (Montigny-le-Bretonneux)
- L'Oreal (Levallois)
- Estee Lauder (Paris)
- Peugeot (Paris)
- Jet Service (Lyon)
- R.P. Scherer (Benheim)
- France Telecom (Paris)
- Becton Dickinson (Le Pont-de-Claix)
- Fould Springer (Marcq-en-Baroeul)
- Boehringer Diagnostics (Meylan)
- Seppic Givaudan Lavirotte (Lyon)
- Le Grand Canal (Villeneuve-Loubet)
- Air Liquide (Paris)
- Carboxyque (Puteaux)
- Klocke (Strasbourg)
- Trophy Radio (Paris)
- Jouan (Saint-Herblain)
- Perkin Elmer (Paris)
- French National Research Agency [ANR-05-PNRA-010]
- French Ministry of Health, Mederic (Paris)
- Sodexo (Issy-les-Moulineaux)
- Ipsen (Boulogne-Billancourt)
- MGEN (Paris)
- Pierre Fabre (Boulogne-Billancourt)
- University of Paris 13
This study's objective was to investigate healthy aging in older French adults 5 years after a period of daily nutritional-dose supplementation with antioxidant nutrients. The study was based on the double-blind, randomized trial, Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) Study (1994-2002) and the SU.VI.MAX 2 Follow-up Study (2007-2009). During 1994-2002, participants received a daily combination of vitamin C (120 mg), beta-carotene (6 mg), vitamin E (30 mg), selenium (100 mu g), and zinc (20 mg) or placebo. Healthy aging was assessed in 2007-2009 by using multiple criteria, including the absence of major chronic disease and good physical and cognitive functioning. Data from a subsample of the SU.VI.MAX 2 cohort, initially free of major chronic disease, with a mean age of 65.3 years in 2007-2009 (n = 3,966), were used to calculate relative risks. Supplementation was associated with a greater healthy aging probability among men (relative risk = 1.16, 95% confidence interval: 1.04, 1.29) but not among women (relative risk = 0.98, 95% confidence interval: 0.86, 1.11) or all participants (relative risk = 1.07, 95% confidence interval: 0.99, 1.16). Moreover, exploratory subgroup analyses indicated effect modification by initial serum concentrations of zinc and vitamin C. In conclusion, an adequate supply of antioxidant nutrients (equivalent to quantities provided by a balanced diet rich in fruits and vegetables) may have a beneficial role for healthy aging.
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