期刊
DYES AND PIGMENTS
卷 158, 期 -, 页码 312-318出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2018.05.026
关键词
Fluorescent sensor; Quinoline; Zinc ion; DFT; Fluorescence imaging
资金
- National Basic Research Program of China [2015CB352005]
- National Natural Science Foundation of China [61775145, 31771584, 61605124, 61620106016, 61525503]
- Guangdong Natural Science Foundation [2014A030312008, 20178020210006]
- Hong Kong, Macao, and Taiwan cooperation innovation platform & major projects of international cooperation in Colleges and Universities in Guangdong Province [2015kgjhz002]
- Shenzhen Basic Research Project [JCYJ20170412110212234, JCYJ20170412105003520, JCYJ20160328144746940, JCYJ20160308093035903, JCYJ20160422151611496, GRCK2017042110420047]
- Hong Kong Polytechnic University [1-ZE1C]
A simple quinoline-based derivative (AQDPA) was developed as a highly efficient fluorescent sensor for sensing Zn2+ and sequential recognition of pyrophosphate and sulfur ions. This chemosensor was synthesized from diisopropylamine and 2-chloro-N-(quinolin-8-yl)acetamide. The non-fluorescence sensor displayed significant and specific fluorescence enhancement after binding to Zn2+ with high selectivity. The fluorescence titration analysis shows a detection limit for Zn2+ at 4.1 x 10(-8) M. The sensing mechanisms of AQDPA binding to Zn2+ were supported by H-1 NMR, HR-MS analysis, and density functional theory (DFT) study. Moreover, the fluorescence imaging in HeLa cells suggested that this simple sensor had great potential in the application of biological imaging.
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