期刊
DYES AND PIGMENTS
卷 150, 期 -, 页码 151-157出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2017.11.047
关键词
pH sensor; Lanthanide; Luminescence; Cellular imaging
资金
- National Natural Science Foundation of China [21371063, 21328503]
- Guangzhou city scientific research fund [2014J4100054]
- Guangdong Science and Technology plan [2016A050502053]
- leading talents of Guangdong province program
- Scientific Research Fund of Henan Provincial Education Department [17A150016]
- Natural Science Foundation of Henan [162300410200]
- Research fund of higher education committee of Guangdong province [GDJ2016003]
A novel terpyridine derivative conjugated by tetraethylene glycol chains with a coordinative europium (III) center was prepared and the assembled complex with high water solubility exhibited sensitive pH dependence. Modulation of the luminescence could be realized at variable physiological pH values (from 8 to 2) by consecutive changes in the form and intensity of both europium and ligand emissions. The achieved multiple optical signal shifts (blue-red-green) and especially the performance of the well-defined lanthanide complex under strong acidic condition had never been reported. In vitro studies revealed that the europium complex was nontoxic to HeLa and THP-1 cells. Fluorescent microscope images supported the distribution of the emissive species and the measurement of pH fluctuations in pathogenic cells could be achieved.
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