期刊
DYES AND PIGMENTS
卷 154, 期 -, 页码 269-274出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2018.02.029
关键词
Dyes; Fluorescence; Cyanine; Nanoparticle; Bioimaging
资金
- Nanyang Assistant Professorship from Nanyang Technological University [M4080992.120]
- AcRF Tier 2 from the Ministry of Education, Singapore [ARC 36/13]
- Nanyang Technological University
Near infrared (NIR) fluorescent molecules with light absorption and emission above 700 nm are important for noninvasive and deep-tissue imaging for disease diagnosis and imaging-guided surgery. Nevertheless, currently available NIR fluorophores with high fluorescence quantum yields and robust photostability remain rather limited. Here we report a series of n-extended pyrrolopyrrole cyanine (PPC gamma) derivatives with tunable light absorption and emission in the NIR spectral region. The extent of the intramolecular charge transfer shows significant effect on the optical bandgap, the Stokes shift and the fluorescence quantum yield. These hydrophobic PPC gamma derivatives were dispersed as colloidal nanoparticles into water via a nanoprecipitation process. The nanoparticles composed of spirofluorene-flanked PPC gamma derivatives exhibit the optimal optical properties, effective tumor-targeting, and high fluorescence contrast for in vivo bioimaging of xenografted tumor-model mice.
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