期刊
DYES AND PIGMENTS
卷 150, 期 -, 页码 139-150出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2017.11.019
关键词
Zinc phthalocyanine; Melanoma; Glutathione; Amide bond; Singlet quantum yield; Nanoconjugates
资金
- Department of Science and Technology (DST) Innovation
- National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]
- Rhodes University
- Council for Scientific and Industrial Research
We report on the synthesis of glutathione capped gold (AuNPs-GSH) and gold-silver (Au(3)Ag(5)NPs-GSH) nano particles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au(3)Ag(1)NPs which afforded decreased activity) in comparison to complex 1.
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