期刊
DRUG AND ALCOHOL DEPENDENCE
卷 190, 期 -, 页码 143-150出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2018.05.024
关键词
Adolescence; Schizophrenia; Polygenic risk score; Cannabis use; Smoking; Alcohol use; Substance use; Genetic
资金
- Dynamics of Youth grant from the University Utrecht, the Netherlands
- Netherlands Organisation for Scientific Research [GB-MAGW 480-03-005, GB-MAGW 480-08-006, 024.001.003]
- Stichting Achmea Slachtoffer en Samenleving (SASS)
- VU University Amsterdam
- Utrecht University
Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13-16 with 16-20 years). Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (p(t)) < 5e-8 to p(t) < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p <= 0.001. Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16-20 (PRS thresholds p(t) < 5e-5 and p(t )< 5e-4; p(t) < 5e 6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds p(t )< 5e-3 to p(t) < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.
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