期刊
DNA AND CELL BIOLOGY
卷 37, 期 6, 页码 517-523出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2017.4118
关键词
TET2; DNA demethylation; atherosclerosis; inflammation
资金
- Natural Science Foundation of China [81070221]
- Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province
- Construct Program of the Key Discipline in Hunan Province
Atherosclerosis is the underlying cause of cardio-cerebrovascular disease. However, the mechanisms of atherosclerosis are still unclear. The modification of DNA methylation has an important role in atherosclerosis development. As a member of the Ten-eleven translocation (TET) family, TET methylcytosine dioxygenase 2 (TET2) can modify DNA methylation by catalyzing 5-methylcytosine to 5-hydroxymethylcytosine and mediate DNA demethylation. Recent findings suggest that TET2 is related to the phenotype transformation of vascular smooth muscle cells, endothelial dysfunction, and inflammation of macrophage, the key factors of atherosclerosis. Therefore, TET2 may be a potential target for atherosclerosis treatment. This review will elaborate the recent findings that suggest the role of TET2 in atherosclerosis.
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