期刊
DNA AND CELL BIOLOGY
卷 37, 期 3, 页码 220-226出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2017.4012
关键词
Alzheimer's disease; lncRNA EBF3-AS; SH-SY5Y; neurons apoptosis
资金
- Gansu Province health industry science research project [GSWSKY-2015-06]
Alzheimer's disease (AD) is the most common form of dementia; its pathophysiological mechanism remains unclear. Long noncoding RNAs (lncRNAs) play key roles in AD. lncRNA EBF3-AS has been found dysregulated in AD, which is abundantly expressed in the brain. The aim of this study was to investigate the role of EBF3-AS in AD. Results showed that the expressions of lncRNA EBF3-AS and EBF3 (early B cell factor 3) were upregulated in hippocampus of APP/PS1 mice (AD model mice). EBF3-AS knockdown by siRNA inhibited the apoptosis induced by A(25-35) and okadaic acid (OA) in SH-SY5Y. The expression of EBF3 was downregulated in A(25-35)- and OA-treated SH-SY5Y, which was reversed by EBF3-AS knockdown. EBF3 knockdown can reverse the A(25-35)-induced apoptosis in SH-SY5Y. These results revealed that lncRNA EBF3-AS promoted neuron apoptosis in AD, and involved in regulating EBF3 expression. EBF3-AS may be a new therapeutic target for treatment of AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据