期刊
CHINESE JOURNAL OF CANCER
卷 34, 期 -, 页码 -出版社
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.1186/s40880-015-0030-x
关键词
Ribosome-inactivating protein (RIP); Anti-tumor; Apoptosis; Cancer
类别
资金
- Basic Research Program of Shenzhen [JCYJ20120613113228732]
- University Innovation Program of Guangdong Province [201410590040]
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
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