期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 90, 期 4, 页码 253-256出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2017.12.002
关键词
CellaVision; Malaria; Diagnosis; Parasitemia
CellaVision DM96 is a digital cell morphology system for automated classification of white and red blood cells. CellaVision Advanced RBC application (ARBCA) pre-classifies RBC in 21 categories, including parasitized RBC, and allows re-classification by the operator. In this study, the performance of the software for detection of malaria and calculation of parasitemia was evaluated and compared to microscopy (n = 40). For CellaVision, both pre- and post-reclassification results were evaluated. Sensitivity was moderate, even post-reclassification (72%), due to low numbers of analyzed RBC and limited resolution of photographs. CellaVision results correlated with microscopy according to Passing-Bablok analysis, with slightly lower values for CellaVision. Within-run, between-run and inter-observer variability were acceptable. The low sensitivity of CellaVision ARBCA precludes its use as a screening technique for malaria. However, due to its good correlation with microscopy and short turnaround-times, it may be useful in follow-up of parasitemia. Larger studies are required to confirm these findings. (C) 2017 Elsevier Inc. All rights reserved.
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