期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 141, 期 -, 页码 132-139出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2018.04.037
关键词
Type 2 diabetes; Aerobic training; Aquatic environment; Land environment; Histone deacetylase; Cytokines
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [476634/2013-0]
- CNPq
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES
Aims: Our purpose was to investigate the effects of aerobic periodized training in aquatic and land environments on plasma histone deacetylase (HDAC) activity and cytokines levels in peripheral blood of diabetes mellitus type 2 (T2DM) patients. Methods: The patients underwent 12 weeks of periodized training programs that including walking or running in a swimming pool (aquatic group) or in a track (dry land group). Blood samples were collected immediately before and after both first and last sessions. Plasma cytokine levels and HDAC activity in peripheral blood mononuclear cell (PBMC) was measured. Results: The exercise performed in both environments similarly modulated the evaluated acetylation mark, global HDAC activity. However, a differential profile depending on the evaluated time point was detected, since exercise increased acutely HDAC activity in sedentary and after 12 weeks of training period, while a reduced HDAC activity was observed following periodized training (samples collected before the last session). Additionally, the 12 weeks of periodized exercise in both environments increased IL-10 levels. Conclusions: Our data support the hypothesis that the modulation of HDAC activity and inflammatory status might be at least partially related to exercise effects on T2DM. The periodized training performed in both aquatic and land environments impacts similarly epigenetic and inflammatory status. (C) 2018 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据