期刊
DIABETES
卷 67, 期 5, 页码 791-804出版社
AMER DIABETES ASSOC
DOI: 10.2337/db17-0983
关键词
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资金
- National Creative Research Initiative Program - Ministry of Education, Science and Technology [2011-0018312]
- Ministry of Science and ICT through the National Research Foundation [2013M3A9D5072550]
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK075040] Funding Source: NIH RePORTER
Beige adipocytes can dissipate energy as heat. Elaborate communication between metabolism and gene expression is important in the regulation of beige adipocytes. Although lipid droplet (LD) binding proteins play important roles in adipose tissue biology, it remains unknown whether perilipin 3 (Plin3) is involved in the regulation of beige adipocyte formation and thermogenic activities. In this study, we demonstrate that Plin3 ablation stimulates beige adipocytes and thermogenic gene expression in inguinal white adipose tissue (iWAT). Compared with wild-type mice, Plin3 knockout mice were cold tolerant and displayed enhanced basal and stimulated lipolysis in iWAT, inducing peroxisome proliferator-activated receptor alpha (PPAR alpha) activation. In adipocytes, Plin3 deficiency promoted PPAR alpha target gene and uncoupling protein 1 expression and multilocular LD formation upon cold stimulus. Moreover, fibroblast growth factor 21 expression and secretion were upregulated, which was attributable to activated PPAR alpha in Plin3-deficient adipocytes. These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression.
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