期刊
DEVELOPMENTAL CELL
卷 45, 期 1, 页码 53-+出版社
CELL PRESS
DOI: 10.1016/j.devcel.2018.02.023
关键词
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资金
- program Investissements d'avenir'' [ANR-10-IAIHU-06]
- ICM
- VIB
- WiBrain Interuniversity Attraction Pole network (Belspo)
- Paul G. Allen Frontiers Group
- Funds for Scientific Research Flanders (Fonds Wetenschappelijke Onderzoeks
- FWO) postdoctoral fellowship
- Becas Chile postdoctoral fellowship
- University of Leuven postdoctoral fellowship (PDM)
- EMBO Long-Term Fellowship
- VIB Omics postdoctoral fellowship
- China Scholarship Council doctoral fellowship
The importance of producing the correct numbers of neurons during development is illustrated by both evolutionary enhancement of cognitive capacities in larger brains, and developmental disorders of brain size. In humans, increased neuronal numbers during development is speculated to partly derive from a unique subtype of neural stem cells (NSCs) that undergo a phase of expansion through symmetric self-amplifying divisions before generating neurons. Symmetric amplification also appears to underlie adult neural stem maintenance in the mouse. However, the mechanisms regulating this behavior are unclear. We report the discovery of self-amplifying NSCs in Drosophila and show that they arise by a spatiotemporal conversion of classical self-renewing NSCs. This conversion is regulated by a temporal transition in the expression of proneural transcription factors prior to cell division. We find a causal link between stem cell self-amplification and increased neuronal numbers. We further show that the temporal transcriptional switch controls both stem cell division and subsequent neuronal differentiation.
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