期刊
DEVELOPMENTAL BIOLOGY
卷 433, 期 2, 页码 118-131出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2017.10.010
关键词
Regeneration; Evolution; Invertebrates; Neoblasts; Stem cells; Piwi
资金
- Human Frontier Science Program Fellowship
- Elizabeth Hannah Jenkinson Fund
- Medical Research Council [MR/M000133/1]
- Biotechnology and Biological Sciences Research Council [BB/K007564/1]
- BBSRC [BB/L026627/1, BB/K007564/1] Funding Source: UKRI
- MRC [MR/M000133/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L026627/1] Funding Source: researchfish
How do animals regenerate specialised tissues or their entire body after a traumatic injury, how has this ability evolved and what are the genetic and cellular components underpinning this remarkable feat? While some progress has been made in understanding mechanisms, relatively little is known about the evolution of regenerative ability. Which elements of regeneration are due to lineage specific evolutionary novelties or have deeply conserved roots within the Metazoa remains an open question. The renaissance in regeneration research, fuelled by the development of modern functional and comparative genomics, now enable us to gain a detailed understanding of both the mechanisms and evolutionary forces underpinning regeneration in diverse animal phyla. Here we review existing and emerging model systems, with the focus on invertebrates, for studying regeneration. We summarize findings across these taxa that tell us something about the evolution of adult stem cell types that fuel regeneration and the growing evidence that many highly regenerative animals harbor adult stem cells with a gene expression profile that overlaps with germline stem cells. We propose a framework in which regenerative ability broadly evolves through changes in the extent to which stem cells generated through embryogenesis are maintained into the adult life history.
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