期刊
DEVELOPMENTAL BIOLOGY
卷 433, 期 2, 页码 200-209出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2017.07.026
关键词
Skeletal muscle; Regeneration; Stem cells; Evolution; Quiescence; Injury
资金
- Institut Pasteur, Agence Nationale de la Recherche (Laboratoire d'Excellence Revive, Investissement d'Avenir) [ANR-10-LABX-73, ANR-06-BLAN-0039]
- European Research Council [332893]
- Doctoral School Fellowship
- Fondation pour la Recherche Medicale [FDT20160435382]
One of the most fascinating questions in regenerative biology is why some animals can regenerate injured structures while others cannot. Skeletal muscle has a remarkable capacity to regenerate even after repeated traumas, yet limited information is available on muscle repair mechanisms and how they have evolved. For decades, the main focus in the study of muscle regeneration was on muscle stem cells, however, their interaction with their progeny and stromal cells is only starting to emerge, and this is crucial for successful repair and re-establishment of homeostasis after injury. In addition, numerous murine injury models are used to investigate the regeneration process, and some can lead to discrepancies in observed phenotypes. This review addresses these issues and provides an overview of some of the main regulatory cellular and molecular players involved in skeletal muscle repair.
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