期刊
DEVELOPMENTAL BIOLOGY
卷 444, 期 -, 页码 S36-S46出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2018.05.018
关键词
Neural crest; Nonneural ectoderm; Neural plate; Signaling; Vertebrate embryo; Gene-regulatory network; BMP; Wnt; FGF; Pax3; Zic1; Msx1/2; Tfap2a; Gbx2; Hes4
资金
- Universite Paris Sud, CNRS
- Agence Nationale pour la Recherche [ANR-15-CE13-0012-01-CRESTNETMETABO]
- Fondation pour la Recherche Medicale (FRM) [DEQ. 20150331733, DGE20111123020]
- Institut Universitaire de France
The neural crest is induced at the edge between the neural plate and the nonneural ectoderm, in an area called the neural (plate) border, during gastrulation and neurulation. In recent years, many studies have explored how this domain is patterned, and how the neural crest is induced within this territory, that also participates to the prospective dorsal neural tube, the dorsalmost nonneural ectoderm, as well as placode derivatives in the anterior area. This review highlights the tissue interactions, the cell-cell signaling and the molecular mechanisms involved in this dynamic spatiotemporal patterning, resulting in the induction of the premigratory neural crest. Collectively, these studies allow building a complex neural border and early neural crest gene regulatory network, mostly composed by transcriptional regulations but also, more recently, including novel signaling interactions.
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