期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 84, 期 -, 页码 62-70出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2018.01.012
关键词
Extracellular traps; Hemocyte; Innate immunity; Periplaneta amerciana
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Extracellular traps (ETs), web-like structures composed of DNA and histones, are released by innate immune cells in a wide range of organisms. ETs capture microorganisms, thereby avoiding their spread, and also concentrate antimicrobial molecules, which helps to kill microbes. Although vertebrate innate immune systems share homology with the insect immune system, ETosis have yet to be characterized in insects. Here, we report that the hemocytes of the hemimetabolous insect Periplaneta americana release ETs upon in vitro stimulation. We further discuss the relationship between ETs and nodulation and in controlling bacterial spread in vivo. (C) 2018 Elsevier Ltd. All rights reserved.
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