期刊
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
卷 2, 期 10, 页码 978-983出版社
WILEY-BLACKWELL
DOI: 10.1002/acn3.251
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资金
- NIDA NIH HHS [R01 DA019674] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007198] Funding Source: Medline
- NIMH NIH HHS [R01 MH051699] Funding Source: Medline
- NINDS NIH HHS [R01 NS048478] Funding Source: Medline
Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin alpha 4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice and also on activated human Jurkat T cells in a manner distinct from nuclear factor erythroid 2-like 2 activation. Our results offer an alternative mechanism for the efficacy of dimethyl fumarate in multiple sclerosis.
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