期刊
DEVELOPMENT
卷 145, 期 6, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.137729
关键词
Transcription; Epigenetics; Development; Genome organization; Cell differentiation
资金
- US Public Health Service Award from the National Institutes of Health [R01 GM035463]
- Direccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico [IN201114, IN203917]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica [IN201114, IN203917]
- Consejo Nacional de Ciencia y Tecnologia [220503, 288814, 25590]
- Fronteras de la Ciencia [2015-290]
CTCF is a highly conserved zinc-finger DNA-binding protein that mediates interactions between distant sequences in the genome. As a consequence, CTCF regulates enhancer-promoter interactions and contributes to the three-dimensional organization of the genome. Recent studies indicate that CTCF is developmentally regulated, suggesting that it plays a role in cell type-specific genome organization. Here, we review these studies and discuss how CTCF functions during the development of various cell and tissue types, ranging from embryonic stem cells and gametes, to neural, muscle and cardiac cells. We propose that the lineage-specific control of CTCF levels, and its partnership with lineage-specific transcription factors, allows for the control of cell type-specific gene expression via chromatin looping.
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