期刊
DEVELOPMENT
卷 145, 期 8, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.143420
关键词
Stem cell; Mitochondria; Cell fate; Aging
资金
- CARIGEST SA
- Sun Yat-sen University
- Canadian Institutes of Health Research
- Kidney Foundation of Canada
- Ecole Polytechnique Federale de Lausanne
- National Institutes of Health [R01AG043930]
- SystemsX [SySX.ch 2013/153]
- Velux Stiftung (Switzerland)
- Swiss National Science Foundation (Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung) [31003A-140780]
The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light and the importance of mitochondria in mediating stem cell activity is becoming increasingly recognized. Despite the fact that many stem cells exhibit low mitochondrial content and a reliance on mitochondrial-independent glycolytic metabolism for energy, accumulating evidence has implicated the importance of mitochondrial function in stem cell activation, fate decisions and defense against senescence. In this Review, we discuss the recent advances that link mitochondrial metabolism, homeostasis, stress responses, and dynamics to stem cell function, particularly in the context of disease and aging. This Review will also highlight some recent progress in mitochondrial therapeutics that may present attractive strategies for improving stem cell function as a basis for regenerative medicine and healthy aging.
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