期刊
EMERGING INFECTIOUS DISEASES
卷 21, 期 10, 页码 1777-1783出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2110.150259
关键词
-
资金
- Rocky Mountain Veterinary Branch
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
In late 2013, the largest documented outbreak of Ebola hemorrhagic fever started in Guinea and has since spread to neighboring countries, resulting in almost 27,000 cases and >11,000 deaths in humans. In March 2014, Ebola virus (EBOV) was identified as the causative agent. This study compares the pathogenesis of a new EBOV strain, Makona, which was isolated in Guinea in 2014 with the prototype strain from the 1976 EBOV outbreak in the former Zaire. Both strains cause lethal disease in cynomolgus macaques with similar pathologic changes and hallmark features of Ebola hemorrhagic fever. However, disease progression was delayed in EBOV-Makona infected animals, suggesting decreased rather than increased virulence of this most recent EBOV strain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据