Validity of anthropometry- and impedance-based equations for the prediction of total body water as measured by deuterium dilution in Cameroonian haemodialysis patients

Background & aims: There is no available information on the validity of anthropometry- and impedance-based equations for predicting total body water (TBW) in Cameroonian haemodialysis patients. This study aimed to validate and develop predictive equations of TBW for Cameroonian haemodialysis patients. Method: TBW in 40 Cameroonian haemodialysis patients (28 men and 12 women) was measured by deuterium dilution and compared with the one predicted by 7 anthropometric and 9 BIA equations. Multiple linear regression analysis was used to develop an equation for predicting TBW as measured by deuterium, from anthropometric parameters. Results: Pure errors in predicting TBW showed unacceptable value for all equations tested. In all the cases, unacceptable discrepancies at individual level for clinical purposes were noted. The following equation was developed and showed a better agreement with the deuterium dilution method: TBW = 13.8994 + 0.0017 x Age + 0.3190 x Weight + 1.8532 x Sex. Conclusion: Further development and cross-validation of anthropometric and BIA prediction equations specific to African heamodialysis patient are needed. Meanwhile, the equation developed in this study which provided a better agreement with the isotope dilution could be use for Cameroonian haemodialysis patients. (C) 2015 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.